[HTML][HTML] The pleckstrin homology domain is the principle link between the insulin receptor and IRS-1
L Yenush, KJ Makati, J Smith-Hall, O Ishibashi… - Journal of Biological …, 1996 - ASBMB
Interaction domains located in the NH 2 terminus of IRS-1 mediate its recognition by the
insulin receptor. Alignment of IRS-1 and IRS-2 reveals two homology regions: the IH1 PH
contains a pleckstrin homology (PH) domain, and the IH2 PTB contains a phosphotyrosine
binding (PTB) domain. A third region in IRS-1 called SAIN was proposed to contain another
functional PTB domain. Peptide competition experiments demonstrated that the IH2 PTB in
IRS-2, like the corresponding domain in IRS-1, binds directly to peptides containing NPXY …
insulin receptor. Alignment of IRS-1 and IRS-2 reveals two homology regions: the IH1 PH
contains a pleckstrin homology (PH) domain, and the IH2 PTB contains a phosphotyrosine
binding (PTB) domain. A third region in IRS-1 called SAIN was proposed to contain another
functional PTB domain. Peptide competition experiments demonstrated that the IH2 PTB in
IRS-2, like the corresponding domain in IRS-1, binds directly to peptides containing NPXY …