abstract O-GlcNAcylation is a form of cytoplasmic and nuclear glycosylation that is found on
many diverse proteins of the cell including RNA polymerase II and its associated
transcription factors, cytoskeletal proteins, nucleoporins, viral proteins, heat shock proteins,
tumor suppressors, and oncogenes. It involves the attachment of a single, unmodified N-
acetylglucosaminyl residue O-glycosidically linked to the hydroxyl groups of serine and
threonine moieties of proteins. It is a highly abundant and dynamic form of posttranslational …