[HTML][HTML] Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection
X Hua, J Sakai, YK Ho, JL Goldstein… - Journal of Biological …, 1995 - ASBMB
Sterol regulatory element-binding proteins (SREBP-1 and SREBP-2) are proteins of~ 1150
amino acids each that are attached to membranes of the endoplasmic reticulum (ER). In
sterol-depleted cells, a protease releases an NH 2-terminal fragment of~ 500 amino acids
that contains a basic helix-loop-helix leucine zipper motif. This fragment enters the nucleus
and stimulates transcription of genes encoding the low density lipoprotein receptor and
enzymes of cholesterol biosynthesis. Prior evidence indicates that the SREBPs are attached …
amino acids each that are attached to membranes of the endoplasmic reticulum (ER). In
sterol-depleted cells, a protease releases an NH 2-terminal fragment of~ 500 amino acids
that contains a basic helix-loop-helix leucine zipper motif. This fragment enters the nucleus
and stimulates transcription of genes encoding the low density lipoprotein receptor and
enzymes of cholesterol biosynthesis. Prior evidence indicates that the SREBPs are attached …