[HTML][HTML] Human neutrophil elastase proteolytically activates the platelet integrin αIIbβ3 through cleavage of the carboxyl terminus of the αIIb subunit heavy chain …
M Si-Tahar, D Pidard, V Balloy, M Moniatte… - Journal of Biological …, 1997 - ASBMB
Neutrophil elastase (NE) and cathepsin G are two serine proteinases released
concomitantly by stimulated polymorphonuclear neutrophils. We previously demonstrated
that while NE by itself does not activate human platelets, it strongly enhances the weak
aggregation induced by a threshold concentration of cathepsin G (threshold of cathepsin
G)(Renesto, P., and Chignard, M.(1993) Blood 82, 139-144). The aim of this study was to
delineate the molecular mechanisms involved in this potentiation process. Two main pieces …
concomitantly by stimulated polymorphonuclear neutrophils. We previously demonstrated
that while NE by itself does not activate human platelets, it strongly enhances the weak
aggregation induced by a threshold concentration of cathepsin G (threshold of cathepsin
G)(Renesto, P., and Chignard, M.(1993) Blood 82, 139-144). The aim of this study was to
delineate the molecular mechanisms involved in this potentiation process. Two main pieces …