Isoform-specific effects of apolipoprotein E (apoE) on neurite outgrowth and the cytoskeleton
are associated with higher intracellular levels of apoE3 than apoE4 in cultured neurons. The
current studies, designed to determine the mechanism for the differential intracellular
accumulation or retention of apoE, demonstrate that apoE3-and apoE4-containing β-very
low density lipoproteins (β-VLDL) possess similar cell binding and internalization and
delivery of cholesterol to the cells. However, as assessed by immunocytochemistry, analysis …