Is Alzheimer's disease an apolipoprotein E amyloidosis?
T Wisniewski, M Lalowski, A Golabek, B Frangione… - The Lancet, 1995 - Elsevier
T Wisniewski, M Lalowski, A Golabek, B Frangione, T Vogel
The Lancet, 1995•ElsevierThe presence of the apolipoprotein E4 allele has been identified as a major risk factor for
late-onset Alzheimer's disease. Apolipoprotein E has also been found
immunohistochemically in Alzheimer's disease lesions. We biochemically isolated amyloid β
from senile plaques and found that a carboxyl-terminal fragment (residues 216-299) of
apolipoprotein E co-purified. In vitro this fragment from recombinant apolipoprotein E could
form amyloid-like fibrils, which were Congo-red positive. Thus senile plaques may contain …
late-onset Alzheimer's disease. Apolipoprotein E has also been found
immunohistochemically in Alzheimer's disease lesions. We biochemically isolated amyloid β
from senile plaques and found that a carboxyl-terminal fragment (residues 216-299) of
apolipoprotein E co-purified. In vitro this fragment from recombinant apolipoprotein E could
form amyloid-like fibrils, which were Congo-red positive. Thus senile plaques may contain …
The presence of the apolipoprotein E4 allele has been identified as a major risk factor for late-onset Alzheimer's disease. Apolipoprotein E has also been found immunohistochemically in Alzheimer's disease lesions. We biochemically isolated amyloid β from senile plaques and found that a carboxyl-terminal fragment (residues 216-299) of apolipoprotein E co-purified. In vitro this fragment from recombinant apolipoprotein E could form amyloid-like fibrils, which were Congo-red positive. Thus senile plaques may contain both amyloid β and apolipoprotein E amyloid fibrils.
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