[HTML][HTML] Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein
AM Fagan, G Bu, Y Sun, A Daugherty… - Journal of Biological …, 1996 - ASBMB
Presence of the ϵ4 allele of apolipoprotein E (apoE) is a risk factor for Alzheimer's disease
(AD), although the mechanism (s) by which it confers this risk is unknown. ApoE may play a
direct role in AD neuropathology by modulating neuronal structure. We previously showed
that apoE3-containing β-very low density lipoprotein (β-VLDL) can stimulate neurite
outgrowth to a significantly greater extent than apoE4-enriched β-VLDL in a central nervous
system-derived neuronal cell line and that this effect is mediated by interaction with the low …
(AD), although the mechanism (s) by which it confers this risk is unknown. ApoE may play a
direct role in AD neuropathology by modulating neuronal structure. We previously showed
that apoE3-containing β-very low density lipoprotein (β-VLDL) can stimulate neurite
outgrowth to a significantly greater extent than apoE4-enriched β-VLDL in a central nervous
system-derived neuronal cell line and that this effect is mediated by interaction with the low …