[HTML][HTML] Receptor-regulated translocation of endothelial nitric-oxide synthase
P Prabhakar, HS Thatte, RM Goetz, MR Cho… - Journal of Biological …, 1998 - ASBMB
The endothelial nitric-oxide synthase (eNOS) is activated by transient increases in
intracellular Ca 2+ elicited by stimulation of diverse receptors, including bradykinin B 2
receptors on endothelial cells. eNOS and B 2 receptors are targeted to specialized signal-
transducing domains in the plasma membrane termed plasmalemmal caveolae. Targeting to
caveolae facilitates eNOS activation following receptor stimulation, but in resting cells, eNOS
is tonically inhibited by its interactions with caveolin, the scaffolding protein in caveolae. We …
intracellular Ca 2+ elicited by stimulation of diverse receptors, including bradykinin B 2
receptors on endothelial cells. eNOS and B 2 receptors are targeted to specialized signal-
transducing domains in the plasma membrane termed plasmalemmal caveolae. Targeting to
caveolae facilitates eNOS activation following receptor stimulation, but in resting cells, eNOS
is tonically inhibited by its interactions with caveolin, the scaffolding protein in caveolae. We …