Nitric oxide and hypercholesterolemia: a matter of oxidation and reduction?
R Wever, E Stroes, TJ Rabelink - Atherosclerosis, 1998 - atherosclerosis-journal.com
In the last two decades the endothelium has emerged as a vital organ that regulates both
vascular tone and structure [1–3]. The endothelium at the same time produces
vasoconstrictor and vasodilator, as well as proliferative and anti-proliferative factors [1–3].
Evidence is accumulating that nitric oxide (NO)-activity is an important determinant in normal
vessel wall homeostasis [4, 5]. In vitro, NO inhibits all key processes involved in the early
pathogenesis of vascular injury and atherosclerosis (Table 1). It is, therefore, of importance …
vascular tone and structure [1–3]. The endothelium at the same time produces
vasoconstrictor and vasodilator, as well as proliferative and anti-proliferative factors [1–3].
Evidence is accumulating that nitric oxide (NO)-activity is an important determinant in normal
vessel wall homeostasis [4, 5]. In vitro, NO inhibits all key processes involved in the early
pathogenesis of vascular injury and atherosclerosis (Table 1). It is, therefore, of importance …