[HTML][HTML] The human proteinase-activated receptor-3 (PAR-3) gene: identification within a PAR gene cluster and characterization in vascular endothelial cells and …
VA Schmidt, WC Nierman, DR Maglott, LD Cupit… - Journal of Biological …, 1998 - ASBMB
Proteolytically activated receptors (PARs) represent an emerging subset of seven
transmembrane G protein-coupled receptors that mediate cell activation events by receptor
cleavage at distinct scissile bonds located within receptor amino termini. Differential
genomic blotting using a yeast artificial chromosome known to contain the PAR-1 and PAR-
2 genes identified the PAR-3 gene within a PAR gene cluster spanning∼ 100 kilobases at
5q13. The PAR-3 gene is relatively small (∼ 12 kilobases); and, like the PAR-1 and PAR-2 …
transmembrane G protein-coupled receptors that mediate cell activation events by receptor
cleavage at distinct scissile bonds located within receptor amino termini. Differential
genomic blotting using a yeast artificial chromosome known to contain the PAR-1 and PAR-
2 genes identified the PAR-3 gene within a PAR gene cluster spanning∼ 100 kilobases at
5q13. The PAR-3 gene is relatively small (∼ 12 kilobases); and, like the PAR-1 and PAR-2 …