[HTML][HTML] Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking: distinct determinants for agonist-triggered versus tonic internalization and …
MJ Shapiro, JA Trejo, D Zeng, SR Coughlin - Journal of Biological …, 1996 - ASBMB
The G protein-coupled thrombin receptor is activated by an irreversible proteolytic
mechanism and, perhaps as a result, exhibits an unusual trafficking pattern in the cell. Naive
receptors tonically cycle between the cell surface and a protected intracellular pool, whereas
receptors cleaved and activated at the cell surface internalize and move to lysosomes.
Toward understanding how these trafficking events are regulated, we examined a series of
receptor mutants. A receptor with alanine substitutions at all potential phosphorylation sites …
mechanism and, perhaps as a result, exhibits an unusual trafficking pattern in the cell. Naive
receptors tonically cycle between the cell surface and a protected intracellular pool, whereas
receptors cleaved and activated at the cell surface internalize and move to lysosomes.
Toward understanding how these trafficking events are regulated, we examined a series of
receptor mutants. A receptor with alanine substitutions at all potential phosphorylation sites …