Cytosolic phospholipase A2
JD Clark, AR Schievella, EA Nalefski, LL Lin - Journal of lipid mediators …, 1995 - Elsevier
Arachidonic acid is liberated from the sn-2 position of membrane glycerophospholipids by
phospholipase A,(PLA,), initiating the production of prostaglandins and leukotrienes,
important inflammatory mediators (Irvine, 1982; Samuelsson et al., 1991). A subset of the
lysophospholipid produced can be converted to platelet activating factor, another potent
mediator of inflammation (Venable et al., 1993). Thus PLA, serves as a key control point for
the biosynthesis of several classes of inflammatory mediators. Recently, we and others have …
phospholipase A,(PLA,), initiating the production of prostaglandins and leukotrienes,
important inflammatory mediators (Irvine, 1982; Samuelsson et al., 1991). A subset of the
lysophospholipid produced can be converted to platelet activating factor, another potent
mediator of inflammation (Venable et al., 1993). Thus PLA, serves as a key control point for
the biosynthesis of several classes of inflammatory mediators. Recently, we and others have …