[HTML][HTML] How MAP Kinases Are Regulated (∗)
MH Cobb, EJ Goldsmith - Journal of Biological Chemistry, 1995 - ASBMB
The closely related MAP kinases.! extracellular signal-regulated protein kinases 1 and 2
(ERK1 and ERK2), are ubiquitous components of signal transduction pathways. ERK1 and
ERK2 are activated by diverse extracellular stimuli and by protooncogene products that
induce proliferation or enhance differentiation (reviewed in Refs. 1 and 2). MAP kinase
phosphorylations have an impact on processes in the cytoplasm, the nucleus, the
cytoskeleton, and the membrane. The variety of signals that conscript the MAP kinase …
(ERK1 and ERK2), are ubiquitous components of signal transduction pathways. ERK1 and
ERK2 are activated by diverse extracellular stimuli and by protooncogene products that
induce proliferation or enhance differentiation (reviewed in Refs. 1 and 2). MAP kinase
phosphorylations have an impact on processes in the cytoplasm, the nucleus, the
cytoskeleton, and the membrane. The variety of signals that conscript the MAP kinase …