Neurotensin elevates hematocrit and plasma levels of the leukotrienes, LTB4, LTC4, LTD4 and LTE4, in anesthetized rats
RE Carraway, DE Cochrane, R Salmonsen, K Muraki… - Peptides, 1991 - Elsevier
The IV injection of neurotensin (NT) into anesthetized rats produced a marked increase in
hematocrit, labored breathing and peripheral blood stasis with cyanosis. This effect could
also be produced by the NT-related peptides, neuromedin-N and xenopsin; however, it was
not observed when nine other biologically active peptides, including bradykinin and
substance P, were tested. Associated with these responses were increases in the plasma
levels of histamine (measured radioenzymatically) and the leukotrienes, LTB4, LTC4, LTD4 …
hematocrit, labored breathing and peripheral blood stasis with cyanosis. This effect could
also be produced by the NT-related peptides, neuromedin-N and xenopsin; however, it was
not observed when nine other biologically active peptides, including bradykinin and
substance P, were tested. Associated with these responses were increases in the plasma
levels of histamine (measured radioenzymatically) and the leukotrienes, LTB4, LTC4, LTD4 …