Impairment of V (D) J recombination in double-strand break repair mutants
GE Taccioli, G Rathbun, E Oltz, T Stamato, PA Jeggo… - Science, 1993 - science.org
GE Taccioli, G Rathbun, E Oltz, T Stamato, PA Jeggo, FW Alt
Science, 1993•science.orgCells maintain the integrity of their genome through an intricate network of repair systems
that recognize and remove lesions from DNA. The only known site-directed recombination
process in vertebrates is the V (D) J recombination of lymphocyte antigen receptor genes. A
large panel of cell lines deficient in DNA repair were tested for the ability to perform V (D) J
recombination after introduction of the RAG-1 and RAG-2 genes. Two mutants failed to
generate normal V (D) J recombination, and further analysis provided evidence for two …
that recognize and remove lesions from DNA. The only known site-directed recombination
process in vertebrates is the V (D) J recombination of lymphocyte antigen receptor genes. A
large panel of cell lines deficient in DNA repair were tested for the ability to perform V (D) J
recombination after introduction of the RAG-1 and RAG-2 genes. Two mutants failed to
generate normal V (D) J recombination, and further analysis provided evidence for two …
Cells maintain the integrity of their genome through an intricate network of repair systems that recognize and remove lesions from DNA. The only known site-directed recombination process in vertebrates is the V(D)J recombination of lymphocyte antigen receptor genes. A large panel of cell lines deficient in DNA repair were tested for the ability to perform V(D)J recombination after introduction of the RAG-1 and RAG-2 genes. Two mutants failed to generate normal V(D)J recombination, and further analysis provided evidence for two distinct nonlymphoid-specific genes that encode factors involved in both DNA repair and V(D)J recombination.
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