[HTML][HTML] Interleukin-4 and Interleukin-13 Differentially Regulate Epithelial Chloride Secretion (∗)
G Zünd, JL Madara, AL Dzus, CS Awtrey… - Journal of Biological …, 1996 - ASBMB
Intestinal epithelia are in intimate contact with subepithelial and intraepithelial lymphocytes.
When stimulated, mucosal lymphocytes generate cytokines that act locally and influence
functional aspects of many cell types. We have previously defined functional epithelial
receptors for interferon-γ, interleukin (IL)-4, and a recently described IL-4-like cytokine IL-13.
In this study, we examine the ion transport properties of T84 cells, a crypt-like epithelial cell
line, following exposure to IL-4 and IL-13. Basolateral exposure of epithelial monolayers to …
When stimulated, mucosal lymphocytes generate cytokines that act locally and influence
functional aspects of many cell types. We have previously defined functional epithelial
receptors for interferon-γ, interleukin (IL)-4, and a recently described IL-4-like cytokine IL-13.
In this study, we examine the ion transport properties of T84 cells, a crypt-like epithelial cell
line, following exposure to IL-4 and IL-13. Basolateral exposure of epithelial monolayers to …