Structural determinants of the action against Escherichia coli of a human inflammatory fluid phospholipase A2 in concert with polymorphonuclear leukocytes
J Weiss, M Inada, P Elsbach, RM Crowl - Journal of Biological Chemistry, 1994 - ASBMB
Extracellular 14-kDa phospholipases A2 (PLA2) in inflammatory exudates can contribute to
bacterial phospholipid (PL) degradation during phagocytosis of Escherichia coli by
polymorphonuclear leukocytes (PMN) and are highly active toward E. coli treated with the
bactericidal/permeability-increasing protein (BPI) purified from PMN. PLA2 activity toward
BPI-treated E. coli varies greatly among members of this conserved family of enzymes and
apparently depends on a cluster of basic residues in a variable surface region near the NH2 …
bacterial phospholipid (PL) degradation during phagocytosis of Escherichia coli by
polymorphonuclear leukocytes (PMN) and are highly active toward E. coli treated with the
bactericidal/permeability-increasing protein (BPI) purified from PMN. PLA2 activity toward
BPI-treated E. coli varies greatly among members of this conserved family of enzymes and
apparently depends on a cluster of basic residues in a variable surface region near the NH2 …