Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth …

C Martin, YY Aimee, BH Jiang, L Davis… - American journal of …, 1998 - Elsevier
OBJECTIVE: Our purpose was to determine whether the increase in fetal cardiac mass and
cardiac output in chronic anemia is accompanied by changes in capillary density or size or
changes in levels of vascular endothelial growth factor and hypoxia-inducible factor 1, a
basic helix-loop-helix transcription factor that has previously been shown to activate
vascular endothelial growth factor gene transcription when cultured cells are subjected to
hypoxia. STUDY DESIGN: Anemia was induced in near-term ovine fetuses by daily …