[HTML][HTML] The nuclear factor κ-B signaling pathway participates in dysregulation of vascular smooth muscle cells in vitroand in human atherosclerosis
T Bourcier, G Sukhova, P Libby - Journal of Biological Chemistry, 1997 - ASBMB
In the lesions of atherosclerosis, vascular smooth muscle cells (SMC) display many
functions characteristic of cytokine activation that likely contribute importantly to ongoing
inflammation during human atherogenesis. The transcription factor nuclear factor κ-B (NFκB)
often mediates the effects of cytokines on target cells, but the identity of Rel family members
important in human SMC activation remains uncertain. In vitro, human SMC express multiple
Rel family members. Of these, dimers of p65 and p50, but not a putative SMC-Rel, comprise …
functions characteristic of cytokine activation that likely contribute importantly to ongoing
inflammation during human atherogenesis. The transcription factor nuclear factor κ-B (NFκB)
often mediates the effects of cytokines on target cells, but the identity of Rel family members
important in human SMC activation remains uncertain. In vitro, human SMC express multiple
Rel family members. Of these, dimers of p65 and p50, but not a putative SMC-Rel, comprise …