Cytokine-endothelial interactions in inflammation, immunity, and vascular injury.
RS Cotran, JS Pober - Journal of the American Society of …, 1990 - journals.lww.com
This paper reviews the evidence that cytokines induce a variety of functional and structural
alterations in endothelium and that cytokine-endothelial interactions play important roles in
the evolution of inflammatory and immune responses. The effect of cytokines, particularly
interleukin-1 and tumor necrosis factor, on leukocyte-endothelial adhesion has led to the
discovery of several endothelial adhesion molecules, and the molecular and biological
characteristics of these are described. Finally, the review discusses the possible contribution …
alterations in endothelium and that cytokine-endothelial interactions play important roles in
the evolution of inflammatory and immune responses. The effect of cytokines, particularly
interleukin-1 and tumor necrosis factor, on leukocyte-endothelial adhesion has led to the
discovery of several endothelial adhesion molecules, and the molecular and biological
characteristics of these are described. Finally, the review discusses the possible contribution …