[HTML][HTML] Immunological and biological properties of Bet v 4, a novel birch pollen allergen with two EF-hand calcium-binding domains
E Engel, K Richter, G Obermeyer, P Briza… - Journal of Biological …, 1997 - ASBMB
We have isolated a cDNA clone coding for a birch pollen allergen, Bet v 4. The deduced
amino acid sequence of Bet v 4 contained two typical EF-hand calcium-binding domains.
Sequence similarities of Bet v 4 to calmodulin are primarily confined to the calcium-binding
domains. However, significant sequence similarities extending outside the Ca 2+-binding
sites were found with a recently described group of pollen-specific allergens of Brassica and
Bermuda grass. Both EF-hand domains of Bet v 4 are able to bind Ca 2+, as demonstrated …
amino acid sequence of Bet v 4 contained two typical EF-hand calcium-binding domains.
Sequence similarities of Bet v 4 to calmodulin are primarily confined to the calcium-binding
domains. However, significant sequence similarities extending outside the Ca 2+-binding
sites were found with a recently described group of pollen-specific allergens of Brassica and
Bermuda grass. Both EF-hand domains of Bet v 4 are able to bind Ca 2+, as demonstrated …