The human IgE network
BJ Sutton, HJ Gould - Nature, 1993 - nature.com
BJ Sutton, HJ Gould
Nature, 1993•nature.comIgE and its receptors are believed to have evolved as a mechanism to protect mammals
against parasites. But other and intrinsically innocuous antigens can subvert this system to
provoke an allergic response. For human populations in industrialized countries, allergy and
asthma now represent a far greater threat than parasitic infection, and the main impetus for
current studies of the IgE system is the hope of understanding and intervening in the
aetiology of allergic diseases.
against parasites. But other and intrinsically innocuous antigens can subvert this system to
provoke an allergic response. For human populations in industrialized countries, allergy and
asthma now represent a far greater threat than parasitic infection, and the main impetus for
current studies of the IgE system is the hope of understanding and intervening in the
aetiology of allergic diseases.
Abstract
IgE and its receptors are believed to have evolved as a mechanism to protect mammals against parasites. But other and intrinsically innocuous antigens can subvert this system to provoke an allergic response. For human populations in industrialized countries, allergy and asthma now represent a far greater threat than parasitic infection, and the main impetus for current studies of the IgE system is the hope of understanding and intervening in the aetiology of allergic diseases.
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