[HTML][HTML] Biochemical and structural analysis of the IgE binding sites on Ara h1, an abundant and highly allergenic peanut protein
DS Shin, CM Compadre, SJ Maleki, RA Kopper… - Journal of Biological …, 1998 - ASBMB
Allergy to peanut is a significant IgE-mediated health problem because of the high
prevalence, potential severity, and chronicity of the reaction. Ara h1, an abundant peanut
protein, is recognized by serum IgE from> 90% of peanut-sensitive individuals. It has been
shown to belong to the vicilin family of seed storage proteins and to contain 23 linear IgE
binding epitopes. In this communication, we have determined the critical amino acids within
each of the IgE binding epitopes of Ara h1 that are important for immunoglobulin binding …
prevalence, potential severity, and chronicity of the reaction. Ara h1, an abundant peanut
protein, is recognized by serum IgE from> 90% of peanut-sensitive individuals. It has been
shown to belong to the vicilin family of seed storage proteins and to contain 23 linear IgE
binding epitopes. In this communication, we have determined the critical amino acids within
each of the IgE binding epitopes of Ara h1 that are important for immunoglobulin binding …