Severe congenital neutropenia: clinical effects and neutrophil function during treatment with granulocyte colony-stimulating factor
B Weston, RF Todd, R Axtell… - The Journal of …, 1991 - translationalres.com
We studied neutrophil function and clinical responses in seven patients with severe
congenital neutropenia (SCN) after they received treatment with recombinant human
granulocyte colony stimulating factor (rhG-CSF). Two subpopulations of patients with SCN
were defined by their pattern of absolute neutrophil response, superoxide production, and
cytochrome b559 levels. One group had an oscillating absolute neutrophil count and
reduced ability to produce superoxide and cytochrome b559 (n= 4), and the second group …
congenital neutropenia (SCN) after they received treatment with recombinant human
granulocyte colony stimulating factor (rhG-CSF). Two subpopulations of patients with SCN
were defined by their pattern of absolute neutrophil response, superoxide production, and
cytochrome b559 levels. One group had an oscillating absolute neutrophil count and
reduced ability to produce superoxide and cytochrome b559 (n= 4), and the second group …