SLEx expression of normal CD 34 positive bone marrow haemopoietic progenitor cells
M Karakantza, FM Gibson, JD Cavenagh… - British journal of …, 1994 - Wiley Online Library
M Karakantza, FM Gibson, JD Cavenagh, SE Ball, MY Gordon, EC Gordon‐Smith
British journal of haematology, 1994•Wiley Online LibraryWe investigated sialylated Lewis x (sLex) antigen expression on CD 34 positive (CD 34+)
haemopoietic progenitors in the bone marrow of eight healthy volunteers using monoclonal
antibodies. We found that in all the samples examined, CD 34+ bone marrow progenitors
strongly expressed the sLex antigen. This contradicts previous publications which reported
sLex expression on malignant blast cells but not on normal CD 34+ progenitor cells.
haemopoietic progenitors in the bone marrow of eight healthy volunteers using monoclonal
antibodies. We found that in all the samples examined, CD 34+ bone marrow progenitors
strongly expressed the sLex antigen. This contradicts previous publications which reported
sLex expression on malignant blast cells but not on normal CD 34+ progenitor cells.
Summary
We investigated sialylated Lewis x (sLex) antigen expression on CD 34 positive (CD 34+) haemopoietic progenitors in the bone marrow of eight healthy volunteers using monoclonal antibodies. We found that in all the samples examined, CD 34+ bone marrow progenitors strongly expressed the sLex antigen. This contradicts previous publications which reported sLex expression on malignant blast cells but not on normal CD 34+ progenitor cells.
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