[HTML][HTML] Identification and characterization of 1, 25-dihydroxyvitamin D3-responsive repressor sequences in the rat parathyroid hormone-related peptide gene
R Kremer, M Sebag, C Champigny… - Journal of Biological …, 1996 - ASBMB
Parathyroid hormone-related peptide (PTHRP) gene transcription is suppressed by 1, 25-
dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), the active metabolite of vitamin D 3. In the present
report, we examined 1, 25 (OH) 2 D 3-mediated repression of PTHRP expression by
transfection of PTHRP promoter/reporter constructs in normal human keratinocytes and by
DNA binding. We localized an element conferring 1, 25 (OH) 2 D 3-mediated repression in
vivo to a 47-base pair (bp) region located− 1121 to− 1075 from the transcriptional start site …
dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), the active metabolite of vitamin D 3. In the present
report, we examined 1, 25 (OH) 2 D 3-mediated repression of PTHRP expression by
transfection of PTHRP promoter/reporter constructs in normal human keratinocytes and by
DNA binding. We localized an element conferring 1, 25 (OH) 2 D 3-mediated repression in
vivo to a 47-base pair (bp) region located− 1121 to− 1075 from the transcriptional start site …