Synthetic tumor-derived human hypercalcemic factor exhibits parathyroid hormone-like vasorelaxation in renal arteries
RJ Winquist, EP Baskin, GP Vlasuk - Biochemical and biophysical research …, 1987 - Elsevier
RJ Winquist, EP Baskin, GP Vlasuk
Biochemical and biophysical research communications, 1987•ElsevierSynthetic human tumor hypercalcemic factor (1–34, hHF) was compared with parathyroid
hormone (human sequence, 1–34; hPTH) for vasorelaxant activity in isolated rabbit renal
artery segments. The hHF exhibited a potent (IC 50= 1.3× 10− 9 M) and profound (98%)
relaxation which was significantly greater in magnitude than that obtained for hPTH (IC 50=
4.5× 10− 9 M; maximal relaxation= 78%). The relaxations to both peptides were
concentration-dependent and not associated with changes in cyclic AMP levels. These …
hormone (human sequence, 1–34; hPTH) for vasorelaxant activity in isolated rabbit renal
artery segments. The hHF exhibited a potent (IC 50= 1.3× 10− 9 M) and profound (98%)
relaxation which was significantly greater in magnitude than that obtained for hPTH (IC 50=
4.5× 10− 9 M; maximal relaxation= 78%). The relaxations to both peptides were
concentration-dependent and not associated with changes in cyclic AMP levels. These …
Abstract
Synthetic human tumor hypercalcemic factor (1–34, hHF) was compared with parathyroid hormone (human sequence, 1–34; hPTH) for vasorelaxant activity in isolated rabbit renal artery segments. The hHF exhibited a potent (IC50 = 1.3×10−9M) and profound (98%) relaxation which was significantly greater in magnitude than that obtained for hPTH (IC50 = 4.5×10−9M; maximal relaxation = 78%). The relaxations to both peptides were concentration-dependent and not associated with changes in cyclic AMP levels. These results demonstrate a parathyroid hormone-like response, independent of adenylate cyclase activation, in isolated renal arteries. Renal vasodilation may be important for the effects on renal function shared by these two peptides.
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