[HTML][HTML] The Novel Structural Motif Gln795–Gln802 in the Integrin β1C Cytoplasmic Domain Regulates Cell Proliferation (∗)
M Fornaro, DQ Zheng, LR Languino - Journal of Biological Chemistry, 1995 - ASBMB
Alternative splicing of the integrin β 1 subunit mRNA generates a variant form, β 1C, with a
unique cytoplasmic domain that differs from β 1 for a 48-amino acid COOH-terminal
sequence. The potential role of this unique sequence in modulating cellular functions was
investigated using Chinese hamster ovary (CHO) 1 cells transiently transfected with cDNAs
coding for human integrin β 1C or β 1 subunits or mutants containing truncated forms of the
β 1C cytoplasmic domain. A differential effect of β 1C and β 1 on cell proliferation was …
unique cytoplasmic domain that differs from β 1 for a 48-amino acid COOH-terminal
sequence. The potential role of this unique sequence in modulating cellular functions was
investigated using Chinese hamster ovary (CHO) 1 cells transiently transfected with cDNAs
coding for human integrin β 1C or β 1 subunits or mutants containing truncated forms of the
β 1C cytoplasmic domain. A differential effect of β 1C and β 1 on cell proliferation was …
