Regulation of mitogen-activated protein kinase activation by the cytoplasmic domain of the α6 integrin subunit
J Wei, LM Shaw, AM Mercurio - Journal of Biological Chemistry, 1998 - ASBMB
We examined the possibility that the α 6A and α 6B cytoplasmic domain variants of the α 6 β
1 integrin differentially activate p42 and p44 mitogen-activated protein (MAP) kinases.
P388D1 macrophages that express equivalent surface levels of either the α 6A β 1 or α 6B β
1 integrin were used to examine this issue. Adhesion to laminin-1 mediated by the α 6A β 1
integrin triggered activation of a substantial fraction of total p42 and p44 MAP kinases as
assessed using a mobility shift assay, immunoblot analysis with a phosphospecific MAP …
1 integrin differentially activate p42 and p44 mitogen-activated protein (MAP) kinases.
P388D1 macrophages that express equivalent surface levels of either the α 6A β 1 or α 6B β
1 integrin were used to examine this issue. Adhesion to laminin-1 mediated by the α 6A β 1
integrin triggered activation of a substantial fraction of total p42 and p44 MAP kinases as
assessed using a mobility shift assay, immunoblot analysis with a phosphospecific MAP …
