[HTML][HTML] Activation of p53-p21 waf1 pathway in response to disruption of cell-matrix interactions
RC Wu, AH Schönthal - Journal of Biological Chemistry, 1997 - ASBMB
The proliferation of most cells is strictly dependent on cell-matrix interactions, a
phenomenon called anchorage dependence. Because tumor cells often are independent of
this regulation, it is important to characterize the molecular pathways that control cellular
proliferation after detachment of cells from their matrix. In this report, we investigated a
possible role of p53 and one of its target genes, p21 waf1/cip1, as components of anchorage-
dependent cell growth control. We found that p53 protein is rapidly activated upon the …
phenomenon called anchorage dependence. Because tumor cells often are independent of
this regulation, it is important to characterize the molecular pathways that control cellular
proliferation after detachment of cells from their matrix. In this report, we investigated a
possible role of p53 and one of its target genes, p21 waf1/cip1, as components of anchorage-
dependent cell growth control. We found that p53 protein is rapidly activated upon the …
