[HTML][HTML] Activation of the p21 Pathway of Growth Arrest and Apoptosis by the β4 Integrin Cytoplasmic Domain (∗)
AS Clarke, MM Lotz, C Chao, AM Mercurio - Journal of Biological Chemistry, 1995 - ASBMB
The integrin α 6 β 4, a receptor for members of the laminin family of basement membrane
components, contributes to the function of epithelial cells and their oncogenically
transformed derivatives. In our efforts to study α 6 β 4-mediated functions in more detail and
to assess the contribution of the β 4 cytoplasmic domain in such functions, we identified a
rectal carcinoma cell line that lacks expression of the β 4 integrin subunit. This cell line,
termed RKO, expresses α 6 β 1 but not α 6 β 4, and it interacts with laminin-1 less avidly than …
components, contributes to the function of epithelial cells and their oncogenically
transformed derivatives. In our efforts to study α 6 β 4-mediated functions in more detail and
to assess the contribution of the β 4 cytoplasmic domain in such functions, we identified a
rectal carcinoma cell line that lacks expression of the β 4 integrin subunit. This cell line,
termed RKO, expresses α 6 β 1 but not α 6 β 4, and it interacts with laminin-1 less avidly than …
