Stimulation of liver growth by exogenous human hepatocyte growth factor in normal and partially hepatectomized rats
K Fjuiwara, S Nagoshi, A Ohno, K Hirata, Y Ohta… - Hepatology, 1993 - journals.lww.com
Human hepatocyte growth factor stimulates DNA synthesis by cultured rat hepatocytes.
When human hepatocyte growth factor prepared from the culture medium of human
embryonic lung fibroblasts was intravenously injected into normal rats and rats after 70%
hepatectomy, it was detected in hepatocytes but not in nonparenchymal cells isolated 30
min after injection. Similar injections of human hepatocyte growth factor at 2-hr intervals for
10 hr significantly increased hepatic DNA content in normal rats at 48 hr, with increased …
When human hepatocyte growth factor prepared from the culture medium of human
embryonic lung fibroblasts was intravenously injected into normal rats and rats after 70%
hepatectomy, it was detected in hepatocytes but not in nonparenchymal cells isolated 30
min after injection. Similar injections of human hepatocyte growth factor at 2-hr intervals for
10 hr significantly increased hepatic DNA content in normal rats at 48 hr, with increased …