[HTML][HTML] Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone
JD Safer, RN Cohen, AN Hollenberg… - Journal of Biological …, 1998 - ASBMB
On positive thyroid hormone response elements (pTREs), thyroid hormone receptor (TR)
binding to DNA in the absence of ligand (thyroid hormone, T 3) decreases transcription
(silencing). Silencing is due to a family of recently described nuclear corepressor proteins
(NCoR and SMRT) which bind to the CoR box in the hinge region of TR. Ligand-dependent
activation of TR is associated with displacement of corepressors and recruitment of
coactivating proteins. Resistance to thyroid hormone (RTH) is due to mutations in the β …
binding to DNA in the absence of ligand (thyroid hormone, T 3) decreases transcription
(silencing). Silencing is due to a family of recently described nuclear corepressor proteins
(NCoR and SMRT) which bind to the CoR box in the hinge region of TR. Ligand-dependent
activation of TR is associated with displacement of corepressors and recruitment of
coactivating proteins. Resistance to thyroid hormone (RTH) is due to mutations in the β …