Bleeding time in laboratory animals. III-Do tail bleeding times in rats only measure a platelet defect?(the aspirin puzzle)
E Dejana, A Quintana, A Callioni, G de Gaetano - Thrombosis research, 1979 - Elsevier
The template bleeding time tested in the present study was not prolonge in rats given aspirin
(single doses ranging from 1 to 200 mg/kg bw). In contrast, bleeding after the transection of
tails immersed in saline at 37° C was significantly longer in aspirin treated than in control
rats. This prolongation was maximal 1 hour after aspirin (200 mg/kg) and was back to normal
within 24 hours, when platelet malondialdehyde formation was still completely inhibited.
Both template and transection bleeding times were significantly prolonged in …
(single doses ranging from 1 to 200 mg/kg bw). In contrast, bleeding after the transection of
tails immersed in saline at 37° C was significantly longer in aspirin treated than in control
rats. This prolongation was maximal 1 hour after aspirin (200 mg/kg) and was back to normal
within 24 hours, when platelet malondialdehyde formation was still completely inhibited.
Both template and transection bleeding times were significantly prolonged in …