Deficiency of both protein C and protein S in a family with ischemic strokes in young adults

H Koller, G Stoll, M Sitzer, M Burk, B Schottler… - Neurology, 1994 - AAN Enterprises
H Koller, G Stoll, M Sitzer, M Burk, B Schottler, HJ Freund
Neurology, 1994AAN Enterprises
Protein C and protein S deficiencies increase the risk of venous thrombosis and pulmonary
embolism, but their role in arterial thrombosis or embolism is controversial. We describe
cerebral ischemia in two young women in a family with inherited deficiencies of both
proteins C and S and provide evidence that a combined deficiency of proteins C and S may
be a high risk factor for ischemic stroke in young adults.
Protein C and protein S deficiencies increase the risk of venous thrombosis and pulmonary embolism, but their role in arterial thrombosis or embolism is controversial. We describe cerebral ischemia in two young women in a family with inherited deficiencies of both proteins C and S and provide evidence that a combined deficiency of proteins C and S may be a high risk factor for ischemic stroke in young adults.
American Academy of Neurology