Reciprocal paracrine interactions between tumour cells and endothelial cells: the 'angiogenesis progression'hypothesis
IT IS currently believed that solid tumours emerge, in part, as a consequence of the loss of
spatial information encoded by the developmental programme of the affected tissue. In
normal intestinal mucosa, for example, both cell number and position are tightly controlled in
order to maintain the physiological sheath-like (quasi two-dimensional) cell topology [l]. In
this case, homeostasis is maintained through multiple levels of regulation of such cellular
processes as proliferation, differentiation and programmed cell death [1, 21, as well as …
spatial information encoded by the developmental programme of the affected tissue. In
normal intestinal mucosa, for example, both cell number and position are tightly controlled in
order to maintain the physiological sheath-like (quasi two-dimensional) cell topology [l]. In
this case, homeostasis is maintained through multiple levels of regulation of such cellular
processes as proliferation, differentiation and programmed cell death [1, 21, as well as …
IT IS currently believed that solid tumours emerge, in part, as a consequence of the loss of spatial information encoded by the developmental programme of the affected tissue. In normal intestinal mucosa, for example, both cell number and position are tightly controlled in order to maintain the physiological sheath-like (quasi two-dimensional) cell topology [l]. In this case, homeostasis is maintained through multiple levels of regulation of such cellular processes as proliferation, differentiation and programmed cell death [1, 21, as well as through intercellular interactions and proper response to varying microenvironmental conditions. In transformed cells, these control mechanisms are gradually compromised, bypassed or ‘highjacked’in order to allow an unrestricted (three-dimensional) tumour growth.
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