Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases.
Laboratory investigation; a journal of technical methods and pathology, 1995•europepmc.org
Background It is generally assumed that unwarranted, excessive neovascularization of the
retina and iris is a direct response to a hypoxic retinal environment. Prompted by our
previous findings that the potent angiogenic factor, vascular endothelial growth factor
(VEGF), is hypoxia-inducible, we used in situ hybridization techniques to examine the thesis
that VEGF functions as the link between retinal ischemia and a pathologic, intraocular,
angiogenic response.
retina and iris is a direct response to a hypoxic retinal environment. Prompted by our
previous findings that the potent angiogenic factor, vascular endothelial growth factor
(VEGF), is hypoxia-inducible, we used in situ hybridization techniques to examine the thesis
that VEGF functions as the link between retinal ischemia and a pathologic, intraocular,
angiogenic response.
Background
It is generally assumed that unwarranted, excessive neovascularization of the retina and iris is a direct response to a hypoxic retinal environment. Prompted by our previous findings that the potent angiogenic factor, vascular endothelial growth factor (VEGF), is hypoxia-inducible, we used in situ hybridization techniques to examine the thesis that VEGF functions as the link between retinal ischemia and a pathologic, intraocular, angiogenic response.
europepmc.org