[HTML][HTML] Human ICE/CED-3 protease nomenclature
ES Alnemri, DJ Livingston, DW Nicholson, G Salvesen… - Cell, 1996 - cell.com
Cell, 1996•cell.com
It is now clear that members of the ICE/CED-3 protease family play key biological roles in
inflammation and mammalian apoptosis. To date, ten homologs of human origin have been
published (Figure 1). The frenetic pace of identification of new homologs has led to
inconsistent and multiple names for many of these enzymes. As a consequence, the general
scientific community is finding it increasingly difficult to follow this provocative and rapidly
moving field. In an effort to remedy this situation, several of us who have been involved in …
inflammation and mammalian apoptosis. To date, ten homologs of human origin have been
published (Figure 1). The frenetic pace of identification of new homologs has led to
inconsistent and multiple names for many of these enzymes. As a consequence, the general
scientific community is finding it increasingly difficult to follow this provocative and rapidly
moving field. In an effort to remedy this situation, several of us who have been involved in …
It is now clear that members of the ICE/CED-3 protease family play key biological roles in inflammation and mammalian apoptosis. To date, ten homologs of human origin have been published (Figure 1). The frenetic pace of identification of new homologs has led to inconsistent and multiple names for many of these enzymes. As a consequence, the general scientific community is finding it increasingly difficult to follow this provocative and rapidly moving field. In an effort to remedy this situation, several of us who have been involved in the identification and characterization of these enzymes have formed a committee, with the objective of proposing a nomenclature for the human members of this protease family that is sensible and easy to use. The purpose of this letter is to outline our recommendations.
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