World distribution of HLA alleles and implications for disease
J Bodmer - Ciba Foundation Symposium 197‐Variation in the …, 2007 - Wiley Online Library
J Bodmer
Ciba Foundation Symposium 197‐Variation in the Human Genome …, 2007•Wiley Online LibraryThe high level of polymorphism of the HLA system makes it useful for the study of diversity in
different populations. However, its relationships with disease susceptibility, resistance and
progression impose selective pressure on population frequencies that must be taken into
consideration. These relationships allow useful studies on the genetic susceptibility to
disease, which can be studied further and may provide us with another tool with which to
examine the history of populations.
different populations. However, its relationships with disease susceptibility, resistance and
progression impose selective pressure on population frequencies that must be taken into
consideration. These relationships allow useful studies on the genetic susceptibility to
disease, which can be studied further and may provide us with another tool with which to
examine the history of populations.
Summary
The high level of polymorphism of the HLA system makes it useful for the study of diversity in different populations. However, its relationships with disease susceptibility, resistance and progression impose selective pressure on population frequencies that must be taken into consideration. These relationships allow useful studies on the genetic susceptibility to disease, which can be studied further and may provide us with another tool with which to examine the history of populations.
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