The involvement of the low density lipoprotein receptor-related protein (LRP) in chylomicron
remnant (CR) catabolism was investigated. Ligand blot analyses demonstrated that beta-
very low density lipoproteins (beta-VLDL) incubated with apolipoprotein E (beta-VLDL+ E)
bound to the LRP and low density lipoprotein receptors, whereas active (receptor-binding)
alpha 2-macroglobulin (alpha 2M) bound only to LRP partially purified from rat liver
membranes. Iodinated beta-VLDL+ E and active alpha 2M showed high affinity binding to …