The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study
F Forette, ML Seux, JA Staessen, L Thijs… - Archives of internal …, 2002 - jamanetwork.com
Background After the double-blind, placebo-controlled Systolic Hypertension in Europe
(Syst-Eur) trial ended in February 1997, randomized patients were offered active study
medication for a further period of observation. Objective To refine the estimates of the long-
term effects of antihypertensive therapy on the incidence of dementia. Methods Eligible
patients had no dementia and were at least 60 years old. Their systolic blood pressure at
entry was 160 to 219 mm Hg, with diastolic blood pressure below 95 mm Hg …
(Syst-Eur) trial ended in February 1997, randomized patients were offered active study
medication for a further period of observation. Objective To refine the estimates of the long-
term effects of antihypertensive therapy on the incidence of dementia. Methods Eligible
patients had no dementia and were at least 60 years old. Their systolic blood pressure at
entry was 160 to 219 mm Hg, with diastolic blood pressure below 95 mm Hg …