[HTML][HTML] The mitochondrial respiratory chain is partially organized in a supercomplex assembly: kinetic evidence using flux control analysis
C Bianchi, ML Genova, GP Castelli, G Lenaz - Journal of Biological …, 2004 - ASBMB
The model of the respiratory chain in which the enzyme complexes are independently
embedded in the lipid bilayer of the inner mitochondrial membrane and connected by
randomly diffusing coenzyme Q and cytochrome c is mostly favored. However, multicomplex
units can be isolated from mammalian mitochondria, suggesting a model based on direct
electron channeling between complexes. Kinetic testing using metabolic flux control
analysis can discriminate between the two models: the former model implies that each …
embedded in the lipid bilayer of the inner mitochondrial membrane and connected by
randomly diffusing coenzyme Q and cytochrome c is mostly favored. However, multicomplex
units can be isolated from mammalian mitochondria, suggesting a model based on direct
electron channeling between complexes. Kinetic testing using metabolic flux control
analysis can discriminate between the two models: the former model implies that each …