Pathogenesis of rheumatoid arthritis: the role of synoviocytes
Y Yamanishi, GS Firestein - Rheumatic Disease Clinics of North America, 2001 - Elsevier
Rheumatoid arthritis (RA) is traditionally considered to be a T-cell–mediated disease.
Additional data have implicated T-cell–independent pathways in its pathogenesis, however,
especially in late stages of the disease. 26, 32 No one can reasonably dispute that RA is a
disease involving immunologic processes34, 84; however, the specific contribution of T cells
as initiators or perpetuators of the disease remains difficult to prove. Non–T-cell elements,
including macrophage-and fibroblast-like synoviocytes (FLS), are capable of producing …
Additional data have implicated T-cell–independent pathways in its pathogenesis, however,
especially in late stages of the disease. 26, 32 No one can reasonably dispute that RA is a
disease involving immunologic processes34, 84; however, the specific contribution of T cells
as initiators or perpetuators of the disease remains difficult to prove. Non–T-cell elements,
including macrophage-and fibroblast-like synoviocytes (FLS), are capable of producing …