Pathways of coagulation activation in situ in rheumatoid synovial tissue
LR Zacharski, FE Brown, VA Memoli, W Kisiel… - Clinical immunology and …, 1992 - Elsevier
Immunohistochemical techniques were applied to rheumatoid synovium in order to detect
components of coagulation and fibrinolysis pathways within these tissues. These techniques
revealed an intact coagulation pathway and plasminogen activator inhibitor-2 associated
with macrophagelike cells that were present throughout these tissues, especially in
subsurface areas. Cell-associated thrombin generation appeared to account for conversion
of abundant fibrinogen to fibrin. Occasional macrophage-like cells also stained for urokinase …
components of coagulation and fibrinolysis pathways within these tissues. These techniques
revealed an intact coagulation pathway and plasminogen activator inhibitor-2 associated
with macrophagelike cells that were present throughout these tissues, especially in
subsurface areas. Cell-associated thrombin generation appeared to account for conversion
of abundant fibrinogen to fibrin. Occasional macrophage-like cells also stained for urokinase …