[HTML][HTML] Use of C4d as a diagnostic adjunct in lung allograft biopsies
CM Magro, AP Harman, D Klinger, C Orosz… - American Journal of …, 2003 - Elsevier
Purpose: Humoral allograft rejection is a defined mechanism for cardiac and renal graft
dysfunction; C4d deposition, a stable component of complement activation, inversely
correlates with graft survival. With the recent recognition of humoral rejection in lung grafts,
we examined C4d's role as a prognostic adjunct in lung allografts. Material and Methods:
Twenty‐three lung recipients underwent biopsies for deterioration in clinical status or routine
surveillance. Clinically unwell patients possessed acute rejection or bronchiolitis obliterans …
dysfunction; C4d deposition, a stable component of complement activation, inversely
correlates with graft survival. With the recent recognition of humoral rejection in lung grafts,
we examined C4d's role as a prognostic adjunct in lung allografts. Material and Methods:
Twenty‐three lung recipients underwent biopsies for deterioration in clinical status or routine
surveillance. Clinically unwell patients possessed acute rejection or bronchiolitis obliterans …