[HTML][HTML] HLA-specific antibodies are risk factors for lymphocytic bronchiolitis and chronic lung allograft dysfunction
AL Girnita, R Duquesnoy, SA Yousem… - American journal of …, 2005 - Elsevier
Bronchiolitis obliterans syndrome (BOS) represents a major limitation in lung
transplantation. While acuterejection is widely considered the most important risk factor for
BOS, the impact of HLA-specific antibodies is less understood. Of 51 lung recipients who
were prospectively tested during a 4.2±1.6-year period, 14 patients developed HLA-specific
antibodies. A multi-factorial analysis was performed to correlate the prevalence of BOS with
HLA antibodies, persistent-recurrent acute rejection (ACR-PR), lymphocyticbronchiolitis, and …
transplantation. While acuterejection is widely considered the most important risk factor for
BOS, the impact of HLA-specific antibodies is less understood. Of 51 lung recipients who
were prospectively tested during a 4.2±1.6-year period, 14 patients developed HLA-specific
antibodies. A multi-factorial analysis was performed to correlate the prevalence of BOS with
HLA antibodies, persistent-recurrent acute rejection (ACR-PR), lymphocyticbronchiolitis, and …