[HTML][HTML] CD4+ 25+ regulatory T cells limit Th1-autoimmunity by inducing IL-10 producing T cells following human lung transplantation
A Bharat, RC Fields, N Steward, EP Trulock… - American Journal of …, 2006 - Elsevier
Chronic human lung allograft rejection is manifested by bronchiolitis obliterans syndrome
(BOS). BOS has a multifactorial etiology. Previous studies have indicated that both cellular
and humoral alloimmunity play a significant role in the pathogenesis of BOS. Recently,
autoimmunity has also been demonstrated to contribute to lung allograft rejection in animal
models. However, the significance of autoimmunity in BOS remains unknown. In this report,
we investigated the role of naturally occurring CD4+ CD25+ regulatory T cells (T-regs) in …
(BOS). BOS has a multifactorial etiology. Previous studies have indicated that both cellular
and humoral alloimmunity play a significant role in the pathogenesis of BOS. Recently,
autoimmunity has also been demonstrated to contribute to lung allograft rejection in animal
models. However, the significance of autoimmunity in BOS remains unknown. In this report,
we investigated the role of naturally occurring CD4+ CD25+ regulatory T cells (T-regs) in …