[HTML][HTML] Anti-type V collagen lymphocytes that express IL-17 and IL-23 induce rejection pathology in fresh and well-healed lung transplants
S Yoshida, A Haque, T Mizobuchi, T Iwata… - American journal of …, 2006 - Elsevier
Immunity to collagen V [col (V)] contributes to lung 'rejection.'We hypothesized that ischemia
reperfusion injury (IRI) associated with lung transplantation unmasks antigenic col (V) such
that fresh and well-healed lung grafts have differential susceptibility to anti-col (V)-mediated
injury; and expression of the autoimmune cytokines, IL-17 and IL-23, are associated with this
process. Adoptive transfer of col (V)-reactive lymphocytes to WKY rats induced grade 2
rejection in fresh isografts, but induced worse pathology (grade 3) when transferred to …
reperfusion injury (IRI) associated with lung transplantation unmasks antigenic col (V) such
that fresh and well-healed lung grafts have differential susceptibility to anti-col (V)-mediated
injury; and expression of the autoimmune cytokines, IL-17 and IL-23, are associated with this
process. Adoptive transfer of col (V)-reactive lymphocytes to WKY rats induced grade 2
rejection in fresh isografts, but induced worse pathology (grade 3) when transferred to …