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Tie1 on for angiogenesis
Current therapies aimed at limiting tumor angiogenesis are based on our understanding of factors that regulate blood vessel sprouting during growth and development. For example, inhibition of...
Published January 16, 2014
Scientific Show Stopper
Marc Feldmann
Sir Marc Feldmann’s research over the last 30 years has focused on the understanding of autoimmune disease, specifically the treatment of rheumatoid arthritis (RA). Sir Marc, now at the Kennedy Institute of Rheumatology at Oxford University, c...
Published January 2, 2014
Conversations with Giants in Medicine
A pharmacological approach to reversing aniridia
Nonsense mutations that lead to PAX6 haploinsufficiency cause congenital aniridia, a panocular condition that results in severe vision defects. Cheryl Gregory-Evans and colleagues hypothesized that suppression of nonsense mutations could in...
Published December 20, 2013
Author's Take
Shedding light on age-promoting agents
Multiple tools have been established to readily evaluate the carcinogenic potential of environmental agents; however, few options are available to examine the ability of an environmental agent to...
Published December 16, 2013
Scientific Show Stopper
Sugar rush
Metabolic changes within the tumor microenvironment include increased glycolysis; however, it not clear if enhanced glycolytic activity is the result of tumorigenesis or an...
Published December 9, 2013
Scientific Show Stopper
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