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Vaccine targeting protects macaques against vaginal infection
In this episode, Ma Luo and colleagues discuss how the anti-PCS T cell responses and the immune environment induced by the PCS vaccine are key correlates of vaccine efficacy...
Published November 3, 2020
Author's Take
JCI's Conversations with Giants in Medicine: C. Ronald Kahn
C. Ronald (Ron) Kahn of the Joslin Diabetes Center at Harvard Medical School is a physician-scientist who illuminated much of what we appreciate about the insulin receptor and the means by which it signals.
Published October 1, 2020
Conversations with Giants in Medicine
Anti-influenza antibody in hemagglutinin head domain interface
In this episode, James Crowe reports a pan-H7 influenza protective human antibody that recognizes an epitope in the hemagglutinin head domain interface and disrupts HA trimers...
Published August 4, 2020
Author's Take
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity
In this episode, Christina Zielinski and Julia Matthias explain that sodium chloride generates anti-inflammatory human Th17 cell responses but is coopted by pro-inflammatory cytokines to amplify Th17 cell pathogenicity and autoimmunity...
Published July 27, 2020
Author's Take
T cells prevent and treat graft-versus-host disease
In this episode, Marco Davila and Brian Betts explain that taking advantage of the differential expression of CD83, human CD83-targeted CAR T cells prevent and treat GVHD, as well as kill myeloid leukemia...
Published July 27, 2020
Author's Take
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